Lecture: "Open question in recombination detectability"

Professor Jotun Hein
Department of Statistics
University of Oxford, Oxford, UK

25 April 2022, 14:00 

Professor Jotun Hein is a 2021/2022 IAS Distinguished Scholar of the Mortimer and Raymond Sackler Institute of Advanced Studies.



Recombination is a powerful evolutionary process that shapes the genetic diversity observed in the populations of many species. Reconstructing genealogies in the presence of recombination from sequencing data is a very challenging problem, as this relies on mutations having occurred on the correct lineages in order to detect the recombination and resolve the placement of edges in the local trees. We investigate the probability of recovering the true topology of ancestral recombination graphs (ARGs) under the coalescent with recombination and gene conversion. We explore how sample size and mutation rate affect the inherent uncertainty in reconstructed ARGs; this sheds light on the theoretical limitations of ARG reconstruction methods. We illustrate our results using estimates of evolutionary rates for several biological organisms; in particular, we find that for parameter values that are realistic for SARS-CoV-2, the probability of reconstructing genealogies that are close to the truth is low.


Tel Aviv University makes every effort to respect copyright. If you own copyright to the content contained
here and / or the use of such content is in your opinion infringing, Contact us as soon as possible >>