Lecture: "Label-free 2-photon imaging of the structural organisaton of peripheral neurones and glia in the enteric ganglia"

Professor Martin Oheim, Director, Saints-Pères Paris Institute
for the Neurosciences, Director of Research, Centre National
de la Recherche Scientifique (CNRS), Université Paris Cité,
Paris, France


23 March 2022, 11:00 

Professor Martin Oheim  is ​2021/2022 IAS Distinguished Scholars of the Mortimer and Raymond Sackler Institute of Advanced Studies.



Common wisdom has it that intuitions, instincts and basic reactions without a rational basis come from ‘gut feeling’. Indeed, the enteric nervous system (ENS) – a dense meshwork of neurones and glia organised in submucosal and myenteric plexuses that controls the function of the gastrointestinal tract – is much more than a primitive outpost of the brain. While the basic circuitry and main neurotransmitters are well-described, recent work - similar to the central nervous system, CNS) has recognised the key roles played by enteric glia in intestinal homeostasis. But although enteric glia share many similarities with CNS astrocytes, there are important differences, and no unique glial marker has been identified. Also, the unexpected complexity provided by this heterogeneous and plastic glial cell population is best studied in intact tissue. In our current work, we present and validate a fast, label-free 3-D imaging technique for rapidly imaging large networks of enteric neurones and glia in their natural habitat, based on intrinsic (autofluorescence and second-harmonic generation) contrast.




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